Arsene Wenger’s side have recovered from a testing start to the season and enjoyed an impressive September – picking up six wins from seven games in all competitions.
Alexis Sanchez and Aaron Ramsey have both been left out of the match day squad, while Andre Carillo has been named on the bench for Watford.
Watford XI: Gomes, Femenia, Mariappa, Britos, Holebas, Doucoure, Kabasele, Pereyra, Cleverley, Richarlison, Gray
Subs: Janmaat, Deeney, Wague, Watson, Carrillo, Capoue, Karnezis
Arsenal XI: Cech, Koscielny, Mertesacker, Monreal, Bellerin, Elneny, Xhaka, Kolasinac, Iwobi, Welbeck, Lacazette
Subs: Ospina, Holding, Coquelin, Wilshere, Ozil, Walcott, Giroud